Tag Archives: gene

Hacking Darwin – Jamie Metzl

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Hacking Darwin

Genetic Engineering and the Future of Humanity

Jamie Metzl

Genre: Life Sciences

Price: $12.99

Publish Date: April 23, 2019

Publisher: Sourcebooks, Inc

Seller: Sourcebooks, Inc.


“A gifted and thoughtful writer, Metzl brings us to the frontiers of biology and technology, and reveals a world full of promise and peril.” — Siddhartha Mukherjee MD, New York Times bestselling author of The Emperor of All Maladies and The Gene Passionate, provocative, and highly illuminating, Hacking Darwin is the must read book about the future of our species for fans of Homo Deus and The Gene .  After 3.8 billion years humankind is about to start evolving by new rules… From leading geopolitical expert and technology futurist Jamie Metzl comes a groundbreaking exploration of the many ways genetic-engineering is shaking the core foundations of our lives — sex, war, love, and death.  At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race.  Enter the laboratories where scientists are turning science fiction into reality. Look towards a future where our deepest beliefs, morals, religions, and politics are challenged like never before and the very essence of what it means to be human is at play. When we can engineer our future children, massively extend our lifespans, build life from scratch, and recreate the plant and animal world, should we? 

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Hacking Darwin – Jamie Metzl

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Nitrogen pollution is a problem as big as climate change. Science might have a fix.

Some think nitrogen pollution may be the greatest danger we face. The Stockholm Resilience Center, an organization that examines the largest threats to natural life-support systems, considers our overuse of nitrogen a more extreme risk to life on Earth than climate change.

But a new paper, published in the journal Nature this week, uncovered a way that we could keep millions of tons of nitrogen fertilizer from evaporating into  the atmosphere and running into the oceans.

Nitrogen is a basic building block of our food, so farmers spread tons of the stuff — in the form of manure, compost, and synthetic fertilizer — on their fields. But only half of this nitrogen makes it into plants. The rest gets chewed up by hungry soil bacteria and turned into a greenhouse gas 300 times worse than carbon dioxide, or gets washed into waterways where it fuels an explosion of algae growth that turns into lakes and oceans into gloopy, oxygen-starved dead zones.

It’s a massive problem that doesn’t get enough attention. If the Earth were a spaceship [eds note: isn’t it?], the control panel’s nitrogen light would be flashing red.

The Stockholm Resilience Center’s estimation of planetary boundariesF. Pharand-Deschênes/Globaïa

Humans accelerated the nitrogen disaster during the “green revolution” of the 1960s with the worldwide adoption of fertilizer-hungry crops. These replaced strains of wheat, rice, and other grains that grew more slowly and conservatively. Grain harvests more than doubled in two decades, but clouds of pollution spread into the air and water. It seemed like a vicious tradeoff.

But this new research suggests that crops can be nitrogen-hoarding and high-yielding at the same time. Before this study came out, it seemed like we had to choose between frugal crops that grow slowly and hoard nitrogen, and spendthrift crops that grow quickly require extravagant nitrogen.

What had looked like a trade-off may simply have been a mistake. The scientists identified a gene that inhibits nitrogen absorption in rice, which had become hyperactive in high-yielding strains, and figured out how to counteract it. This gene (metaphorically) shouts, “Don’t suck up nitrogen!” Through breeding, scientists were able to turn down the volume of this shout to a whisper. The result is high-yielding rice that needs less fertilizer.

A rice-breeding program to bring this breakthrough to farmers is underway in China, where nitrogen pollution is especially bad. It will take about five years before we really know if this works for farmers outside of greenhouses and test plots. If it does, it might change that nitrogen warning on spaceship earth’s dashboard from red to yellow.

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Nitrogen pollution is a problem as big as climate change. Science might have a fix.

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The Wandering Gene and the Indian Princess: Race, Religion, and DNA – Jeff Wheelwright

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The Wandering Gene and the Indian Princess: Race, Religion, and DNA
Jeff Wheelwright

Genre: Life Sciences

Price: $1.99

Publish Date: January 16, 2012

Publisher: W. W. Norton & Company

Seller: W. W. Norton


A brilliant and emotionally resonant exploration of science and family history. A vibrant young Hispano woman, Shonnie Medina, inherits a breast-cancer mutation known as BRCA1.185delAG. It is a genetic variant characteristic of Jews. The Medinas knew they were descended from Native Americans and Spanish Catholics, but they did not know that they had Jewish ancestry as well. The mutation most likely sprang from Sephardic Jews hounded by the Spanish Inquisition. The discovery of the gene leads to a fascinating investigation of cultural history and modern genetics by Dr. Harry Ostrer and other experts on the DNA of Jewish populations. Set in the isolated San Luis Valley of Colorado, this beautiful and harrowing book tells of the Medina family’s five-hundred-year passage from medieval Spain to the American Southwest and of their surprising conversion from Catholicism to the Jehovah’s Witnesses in the 1980s. Rejecting conventional therapies in her struggle against cancer, Shonnie Medina died in 1999. Her life embodies a story that could change the way we think about race and faith.

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The Wandering Gene and the Indian Princess: Race, Religion, and DNA – Jeff Wheelwright

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Jesmyn Ward’s Resistance Reading

Mother Jones

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We asked a range of authors and creative types to suggest books that bring solace and/or understanding in this age of rancor. More than two dozen responded. Jesmyn Ward—an associate professor of English at Tulane University whose novel Salvage the Bones landed her a 2011 National Book Award—has a highly anticipated new novel due out in September. The book, intriguingly titled Sing, Unburied, Sing, is set in her native Mississippi. She wants you to read it, of course. And she also wants you to read the following.

Latest book: The Fire This Time (editor)
Also known for: Men We Reaped
Reading recommendations: The Half Has Never Been Told: Slavery and the Making of American Capitalism: Author Edward E. Baptist builds a very compelling argument that slavery made the foundation and growth of the United States, as an independent country, possible. This book is so necessary because it seems we live in a time where those in power are invested in willful ignorance, “alternative facts,” and a revisionist view of the kind of real pain, suffering, and dehumanization that actually allowed this country to ascend to “greatness.” We need books like this to shine light on the darkness that beats at the heart of America today.

Earth in Human Hands: Shaping Our Planet’s Future, by David Grinspoon: Contrary to what our dear leader believes, climate change is not a hoax perpetrated by the Chinese. It is real. This book provides a sobering exploration of how human beings have affected the climate of our planet, but also gives us reason to hope in the end. We need that now.
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The series so far: Daniel Alarcón, Kwame Alexander, Margaret Atwood, W. Kamau Bell, Ana Castillo, Jeff Chang, T Cooper, Michael Eric Dyson, Dave Eggers, Reza Farazmand, William Gibson, Piper Kerman, Phil Klay, Alex Kotlowitz, Bill McKibben, Rabbi Jack Moline, Siddhartha Mukherjee, Peggy Orenstein, Wendy C. Ortiz, Darryl Pinckney, Joe Romm, Karen Russell, George Saunders, Tracy K. Smith, Ayelet Waldman, Jesmyn Ward, and Gene Luen Yang. (New posts daily.)

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Jesmyn Ward’s Resistance Reading

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Joe Romm’s Resistance Reading

Mother Jones

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We asked a range of authors, artists, and poets to name books that bring solace or understanding in this age of rancor. Two dozen or so responded. Here are picks from the climate change expert, editor, and blogger extraordinaire Joe Romm.

Latest book: Climate Change: What Everyone Needs to Know
Also known for: Founding and editing of ClimateProgress.org
Reading recommendations: As a blogger, I am drawn toward collections of short essays. The last time this country was so divided, the greatest orator and writer ever elected president repeatedly shared his thoughts on what the country needed to do to preserve liberty. Abraham Lincoln: His Speeches and Writings, edited by Roy Basler and Carl Sandburg, is one of the best collections. It includes classics like the Gettysburg Address alongside lesser-known gems like “The Perpetuation of Our Political Institutions,” in which a 28-year-old Lincoln explains the danger to the Republic of a demagogue just like Trump.

A Collection of Essays, by George Orwell: Orwell is so relevant today, 67 years after his death, that he was, as of late, ranked as Amazon’s No. 1 author in both “classics” and “contemporary” literature and fiction! He is also the greatest essayist of the last century, and few essays speak better to our alternative-facts president than 1946’s “Politics and the English Language,” in which Orwell explains why “in our time, political speech and writing are largely the defence of the indefensible.”

Brave New World Revisited, by Aldous Huxley: Brave New World, published in 1932, envisioned a dystopian future for humanity. In 1956, Huxley published a series of essays on the topic that are as relevant today as Orwell’s, with titles like “Propaganda in a democratic society” and “Subconscious persuasion.” A particular must-read is Huxley’s 1949 letter to Orwell about which of their dystopias would turn out to be more prescient.
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So far in this series: Daniel Alarcón, Kwame Alexander, Margaret Atwood, W. Kamau Bell, Ana Castillo, Jeff Chang, T Cooper, Michael Eric Dyson, Dave Eggers, Reza Farazmand, William Gibson, Piper Kerman, Phil Klay, Alex Kotlowitz, Bill McKibben, Rabbi Jack Moline, Siddhartha Mukherjee, Peggy Orenstein, Wendy C. Ortiz, Darryl Pinckney, Joe Romm, Karen Russell, George Saunders, Tracy K. Smith, Ayelet Waldman, Gene Luen Yang. (New posts daily.)

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Joe Romm’s Resistance Reading

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Ayelet Waldman’s Resistance Reading

Mother Jones

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Claire Lewis

We asked a range of authors, artists, and poets to name books that bring solace or understanding in this age of rancor. Two dozen or so responded. Here are picks from the witty and thoughtful Ayelet Waldman, whose recent book about microdosing with LSD caused a bit of a stir in the straight world.

Latest book: A Really Good Day
Also known for: Bad Mother
Reading recommendations: It was as if Mohsin Hamid knew exactly what would convulse the world when he wrote Exit West. It’s a novel about refugees, about cruelty and empathy and compassion, and in the end—oddly—about the possibility of an odd kind of redemption. I am surely not going to be the only one who recommends George Saunders Lincoln in the Bardo, but listening to the audiobook (something I don’t normally do) was one of the most transporting literary experiences of my life. It was both a refuge (I’d put in my earbuds and hide from the horrors of the news) and an inspiration. Led by a brave, brilliant, and indeed tormented man, this nation rejected slavery. It is at least possible that we will one day reject racism, xenophobia, misogyny and all the various tyrannies of this foul administration and the vicious moron who leads it.
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So far in this series: Kwame Alexander, Margaret Atwood, W. Kamau Bell, Jeff Chang, T Cooper, Dave Eggers, Reza Farazmand, Piper Kerman, Phil Klay, Alex Kotlowitz, Bill McKibben, Rabbi Jack Moline, Siddhartha Mukherjee, Peggy Orenstein, Wendy C. Ortiz, Karen Russell, Tracy K. Smith, Ayelet Waldman, Gene Luen Yang. (New posts daily.)

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Ayelet Waldman’s Resistance Reading

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Alex Kotlowitz’s Resistance Reading

Mother Jones

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We asked a range of authors, artists, and poets to name books that bring solace or understanding in this age of rancor. Two dozen or so responded. Here are picks from award-winning long-form journalist and best-selling author Alex Kotlowitz.

Latest book: Never a City So Real
Also known for: There Are No Children Here
Reading recommendations: I’ve been consuming far too much news lately, and so am getting far too agitated with far too much regularity. I need shoring up. I need reassurance that we’ll get through. And so on my night table sit my reinforcements. I’m in the midst of Dutch writer Tommy Wieringa’s These Are the Names, a haunting tale about migration, about faith, and about new beginnings. Colson Whitehead’s The Underground Railroad: Whitehead is a writer of such unflinching honesty and empathy, both of which are in short supply these days. And from someone who knows how deeply the present is informed by the past, Joseph Ellis’ Founding Brothers.

For all the obvious reasons (yes, Mr. Trump, history matters), I’m revisiting former Sen. Paul Simon’s Freedom’s Champion: Elijah Lovejoy. As if we need reminding what happens when good and decent people don’t stand up against the onerous assault on a free press.

And Hanya Yanagihara’s The People in the Trees. Just because.
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So far in this series: Kwame Alexander, Margaret Atwood, W. Kamau Bell, Jeff Chang, T Cooper, Dave Eggers, Reza Farazmand, Piper Kerman, Phil Klay, Alex Kotlowitz, Bill McKibben, Rabbi Jack Moline, Siddhartha Mukherjee, Peggy Orenstein, Wendy C. Ortiz, Karen Russell, Tracy K. Smith, Gene Luen Yang. (New posts daily.)

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Alex Kotlowitz’s Resistance Reading

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Gene Luen Yang’s Resistance Reading

Mother Jones

We asked a range of authors, artists, and poets to name books that bring solace and/or understanding in this age of rancor. Two dozen or so responded. Here are the recommendations from the acclaimed graphic novelist Gene Luen Yang, a repeat National Book Award finalist who, by the way, reinvented Superman.

Illustration by Allegra Lockstadt

Latest book: Superman and Secret Coders book series
Also known for: American Born Chinese
Reading recommendations: The Righteous Mind, by Jonathan Haidt, was a revelation to me when I read it a few years ago. Professor Haidt is a social psychologist. His book helped me understand folks who think differently from me just a little bit better. Silence, by Shusaku Endo, is probably my favorite fiction book of all time. It’s about a Catholic missionary to 17th century Japan who eventually loses his faith. The story reminds me that grace can be found even when things are horribly broken.
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So far in this series: Kwame Alexander, Margaret Atwood, W. Kamau Bell, Jeff Chang, T Cooper, Dave Eggers, Reza Farazmand, Piper Kerman, Bill McKibben, Rabbi Jack Moline, Karen Russell, Tracy K. Smith, Gene Luen Yang. (New posts daily.)

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Gene Luen Yang’s Resistance Reading

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Will Trump’s EPA Greenlight a Pesticide Known to Damage Kids’ Brains?

Mother Jones

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By Friday, President Donald Trump’s Environmental Protection Agency will have to make a momentous decision: whether to protect kids from a widely used pesticide that’s known to harm their brains—or protect the interests of the chemical’s maker, Dow AgroSciences.

The pesticide in question, chlorpyrifos, is a nasty piece of work. It’s an organophosphate, a class of bug killers that work by “interrupting the electrochemical processes that nerves use to communicate with muscles and with other nerves,” as the Pesticide Encyclopedia puts it. Chlorpyrifos is also an endocrine disrupter, meaning it can cause “adverse developmental, reproductive, neurological, and immune effects,” according to the National Institutes of Health.

Major studies from the Mount Sinai School of Medicine, the University of California-Davis, and Columbia University have found strong evidence that low doses of chlorpyrifos inhibits kids’ brain development, including when exposure occurs in the womb, with effects ranging from lower IQ to higher rates of autism. Several studies—examples here, here, and here—have found it in the urine of kids who live near treated fields. In 2000, the EPA banned most home uses of the chemical, citing risks to children.

Stephanie Engel, an epidemiologist at the University of North Carolina and a co-author of the Mount Sinai paper, says the evidence that chlorpyrifos exposure causes harm is “compelling”—and is “much stronger” even than the case against BPA (bisphenol A), the controversial plastic additive. She says babies and fetuses are particularly susceptible to damage from chlorpyrifos because they metabolize toxic chemicals more slowly than adults do. And “many adults” are susceptible, too, because they lack a gene that allows for metabolizing the chemical efficiently, Engel adds.

But even after banning chlorpyrifos from the home, the EPA allowed farms to continue spraying it, and while its US use has declined in recent years, it remains quite high, widely used on corn and soybeans in the Midwest and on fruit, vegetable, and orchard crops in Washington state, California, and the Southeast. California is home to about fifth of all the chlorpyrifos applied on US farms. There, the main target crops are alfalfa, almonds, pistachios, walnuts, tomatoes, and strawberries.

In October 2015, after a review spanning more than a decade, the EPA concluded that exposure to chlorpyrifos posed an unacceptable risk to human health, both from residues on food and in drinking water, and proposed a new rule that would effectively ban farm use of it. The agency also expressed concern about “workers who mix, load and apply chlorpyrifos to agricultural and other non-residential sites and workers re-entering treated areas after application.”

The EPA then dragged its feet on finalizing the rule; but in August 2016, a US Federal Appeals court demanded that a decision be made by March 31, 2017, chastising the agency for its “continued failure to respond to the pressing health concerns presented by chlorpyrifos.”

A few moths after that order, of course, Trump won the presidency, and so his EPA team will make the final decision on chlorpyrifos. Uh-oh. Trump often trumpets his own hostility to regulation and has backed it up by proposing a 31 percent cut in the EPA’s budget. Before taking office, Trump looked to Myron Ebell of the hyper-libertarian Competitive Enterprise Institute to lead the EPA’s transition. Ebell focuses mainly on denying climate change and promoting fossil fuels, but as I noted in November, CEI runs a website, SafeChemicalPolicy.org, that exists to downplay the health and ecological impacts of pesticides.

Trump’s pick to lead the EPA, former Oklahoma Attorney General Scott Pruitt, is a non-scientist with little track record in assessing the health risks posed by chemicals. But he does hew to Trump’s general hostility to regulation. At his confirmation hearings, Pruitt couldn’t name a single EPA regulation he supports, and he even declined to say whether he’d finalize the EPA’s proposed ban on asbestos.

Meanwhile, Dow and the pesticide industry trade group Croplife America are pushing the EPA to backtrack on the chlorpyrifos ban. “The court ordered EPA to make a final decision on the petition by March 31, 2017, but did not specify what that decision should be,” Dow noted in a November 10 press release urging the agency to maintain the status quo.

Dow AgroScience’s parent company, Dow Chemical, has also been buttering up Trump. The company contributed $1 million to the president’s inaugural committee, the Center for Public Integrity notes. In December, Dow Chemical Chairman and CEO Andrew Liveris attended a post-election Trump rally in the company’s home state of Michigan, and used the occasion to announce plans to create 100 new jobs and bring back another 100 more from foreign subsidiaries. Around the same time, Trump named Liveris chair of the American Manufacturing Council, declaring the chemical exec would “find ways to bring industry back to America.” (Dow has another reason beside chlorpyrifos’ fate to get chummy with Trump: its pending mega-merger with erstwhile rival DuPont, which still has to clear Trump’s Department of Justice.)

Kristin S. Schafer, policy director for the Pesticide Action Network, says it would be highly unusual for the EPA to backtrack on a decision to ban a chemical after so strongly signaling that it would. (PAN is one of the advocacy groups that sued the EPA in 2014 over its previous lack of action on chlorpyrifos.) But she added that “all bets are off with this administration.”

She pointed out that the EPA and Dow have been battling over the chemical since the Clinton administration. Back in 1996, the agency fined the company $732,000 for failing to disclose more than 100 reports of chlorpyrifos poisoning. “These reports are particularly important,” the agency complained, because chemicals enter the marketplace without any human testing, and poisoning notices “may document effects not seen in animal studies, or indicate areas which warrant further research.” Most of those alleged poisoning incidences involved exposure in the home—chlorpyrifos was then the most-used household and yard insect-killer. By 2000, as noted above, the EPA had seen fit to ban most home uses of the insect killer.

In an analysis of the risks posed by chlorpyrifos released in November 2016, the EPA crunched data on residues found in food and compared them to the levels at which the chemical can harm the most vulnerable populations: kids and women of child-bearing age. The results (found on page 23 of the EPA doc) are startling. Natural Resources Defense Council researchers turned them into this handy graphic:

NRDC

It would be quite something for the Trump administration to dismiss such overwhelming evidence from EPA scientists and continue allowing chlorpyrifos to be sprayed on crops with few restrictions. But he has already displayed a willingness to trash the agency’s rule-making process to placate his Big Ag supporters.

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Will Trump’s EPA Greenlight a Pesticide Known to Damage Kids’ Brains?

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Here Are the Very Best Signs From New York City’s Big LGBT Solidarity March

Mother Jones

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Emptying out from brunch spots wielding wickedly pointed signs, and chanting, “We want a leader, not a creepy tweeter!” thousands of anti-Trump demonstrators from the LGBT community met for a rally on hallowed turf on Saturday afternoon: the plaza outside the Stonewall nightclub in New York City’s West Village—recently designated by the Obama administration as a National Monument for its historic role in the long fight for gay rights.

Eugene Lovendusky, 31, works in not-for-profit financing in New York City. James West

Chuck Schumer (D-N.Y.), the Senate minority leader, received a mixed reception when he appeared in front of the microphone. “Grow some balls!” several people shouted. “Block everything!”—a reference to the ground-swell of progressive voters demanding Schumer lead Senate Democrats in styming President Trump’s agenda and appointments. (Protesters also gathered on Tuesday night outside the minority leader’s Brooklyn apartment.)

Schumer’s pledge to block Betsy DeVos, Trump’s pick for education secretary—”She can take her conversion therapy back to Michigan!”—was, on the other hand, met with cheers and applause.

James West

But it was clear from talking to multiple people in the LGBT community and their allies on this chilly but sunny Saturday that battle-lines have been drawn: many felt there could be no compromise with the Trump administration.

“It’s time to stop giving in,” said Alan Brodherson, a 52-year-old attorney. “Over the years, that’s what the Democrats have consistently done.”

“I don’t believe in complacency,” he said. “Be vigilant.”

Taylor James, a 29-year-old Canadian dancer and photographer who now lives in Los Angeles, was also impressed by the renewed sense of purpose amongst protesters. “It’s inspiring. In 50 years, in 40 years, I’ll look back to see how I stood up,” he said. “It feels very personal.”

Trump, he said, “forces us to show up.”

Taylor James, 29: “When you’re a liberal, you’re fighting to get to ground zero.”

Most people I spoke to said they turned up to show solidarity with the immigrants and refugees targeted by President Donald Trump’s executive order temporarily barring travel from seven predominantly Muslim countries, along with suspending America’s refugee program. (The Trump administration suffered a set-back on Friday night when Judge James Robart of Federal District Court in Seattle issued an order temporarily blocking Trump’s executive action.)

Jaimie McGovern, 29, showed up simply because “the LGBT community is across every spectrum. We’re Muslim, we’re Hispanic.” She surveyed the turnout: “This is fantastic.”

Marissa Nargi, left, and Jaimie McGovern, both students, turned out to show their support for immigrants and refugees. James West

“We’re not going to stand by while Trump takes away rights one by one,” said IT worker David Vazquez, 31. “It seems like every day he comes out with something new. We need to keep from being discouraged.”

Mike Hisey, dressed as Kellyanne Conway with a blond wig and an outfit that evoked her now-famous inauguration getup, stood outside Stonewall itself, attracting a constant stream of requests for photographs with a deadpan face. “Protesting and march works,” he said.

“I’ve been protesting for 30 years.”

Mike Hisey, a.k.a. “Alt-Fact Kelly,” outside Stonewall nightclub in Manhattan’s West Village. James West

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Here Are the Very Best Signs From New York City’s Big LGBT Solidarity March

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