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Here’s Why OxyContin Is So Damn Addictive

Mother Jones

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Why has OxyContin become the poster child for opioid abuse? The LA Times has a long investigative piece today which suggests that a big part of the blame should be laid at the feet of Purdue Pharma, the makers of the drug. When OxyContin was launched, it was billed as a painkiller that would last 12 hours—longer than morphine and other opioids. That 12-hour dosing schedule was critical to its success. Without it, Oxy didn’t have much benefit. Unfortunately, it turned out that it wore off sooner for a lot of people:

Experts said that when there are gaps in the effect of a narcotic like OxyContin, patients can suffer body aches, nausea, anxiety and other symptoms of withdrawal. When the agony is relieved by the next dose, it creates a cycle of pain and euphoria that fosters addiction, they said.

OxyContin taken at 12-hour intervals could be “the perfect recipe for addiction,” said Theodore J. Cicero, a neuropharmacologist at the Washington University School of Medicine in St. Louis and a leading researcher on how opioids affect the brain.

Patients in whom the drug doesn’t last 12 hours can suffer both a return of their underlying pain and “the beginning stages of acute withdrawal,” Cicero said. “That becomes a very powerful motivator for people to take more drugs.”

But Purdue refused to accept shorter dosing schedules, since that would eliminate its strongest competitive advantage. Instead, they launched a blitz aimed at doctors, telling them to stick with the 12-hour dosing but to prescribe larger amounts. Sometimes this worked and sometimes it didn’t, and when it didn’t it increased the chances of addiction:

In the real world practice of medicine, some doctors turned away from OxyContin entirely. San Francisco public health clinics stopped dispensing the painkiller in 2005, based in part on feedback from patients who said it wore off after eight hours. The clinics switched to generic morphine, which has a similar duration and costs a lot less.

“What I had come to see was the lack of evidence that it was any better than morphine,” Dr. Mitchell Katz, then head of the San Francisco public health department, said in an interview.

The whole piece is worth a read. Purdue has known from the start that 12-hour dosing didn’t work for a significant number of patients, but they relentlessly focused their marketing in that direction anyway. Why? Because without it, Oxy wouldn’t be a moneymaker. As for the danger this posed, that was mostly suppressed by keeping documents under seal in court cases “in order to protect trade secrets.” Welcome to the American pharmaceutical industry.

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Here’s Why OxyContin Is So Damn Addictive

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New York’s natural gas pipelines are leakier than your grandpa

New York’s natural gas pipelines are leakier than your grandpa

By on 10 Sep 2015commentsShare

Just like us, natural gas pipelines get a little farty with old age. Unlike us, they fart loads of climate change-inducing methane all over our city streets like silent Earth assassins. (Technically, we also fart methane, but according to this scientist and self-proclaimed “connoisseur of fart articles,” we don’t fart enough of it to do much damage.)

In a new study published in the journal Environmental Science & Technology Letters, researchers report that — surprise! — old pipes get leaky. And when those pipes are carrying natural gas, that means trouble. Here’s the scoop from Buzzfeed:

The new survey found 1,050 methane leaks in Manhattan, or about four leaks per mile. Two cities selected for comparison — Cincinnati, Ohio, and Durham, North Carolina — had about 90% fewer leaks per mile, the study found. Over the last decade, Cincinnati and Durham have replaced most of their old gas mains with new ones.

“Older iron pipes are corroded, they leak from the joints, they crack and they buckle,” Stanford University’s Robert Jackson, who led the street survey, told BuzzFeed News. “The good news is that some cities are already doing something and showing we can do something about these leaks.”

Fortunately, the New York utility company Con Edison has a $6.5 billion plan to replace 60 percent of its natural gas pipes by 2020, Buzzfeed reports, and is now doing 13 annual leak patrols, rather than one. Unfortunately, this problem isn’t unique to Manhattan. The researchers found that Boston and Washington, D.C., were also quite leaky. Twelve leaks in D.C. were so concentrated, in fact, that they posed explosion risks, according to Buzzfeed. Most of the other leaks just smelled like rotten eggs, which I guess is pretty good in comparison.

But if you don’t care about the smells, the mortal danger, or the fact that methane traps WAY more heat than CO2, then maybe this will get your attention:

“Everyone pays for these leaks. The utilities just jack up their rates to cover the losses so there is no incentive to fix them,” study co-author Robert Ackley of Gas Safety Inc. in Southborough, Massachusetts told BuzzFeed News. “They get away with a lot, in my opinion.”

Ackley, a libertarian, community-college drop-out from Boston, was the star of this 2013 article in Matter about the leaky pipe epidemic. It’s a fascinating read about a fascinating guy. Here’s a teaser:

Few people understand the streets of America’s cities the way Ackley does. He’s spent almost three decades documenting leaky gas pipelines and alerting utility companies to potential danger. Now he can read the street like a hunter reads animal tracks; some academics call him the “urban naturalist.”

As John Oliver pointed out so well earlier this year, infrastructure might be boring, but it’s insanely important to the health and wellbeing of this country. So perhaps we should treat it with the same care and respect that we treat our corroded and leaky elders — if not out of the goodness of our hearts, then because it’s the right thing to do, and if not because it’s the right thing to do, then because people will judge us if we don’t.

Source:

Experts Have Just Found Gas Leaking Out Of 1,000 Spots In New York City

, Buzzfeed.

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New York’s natural gas pipelines are leakier than your grandpa

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